Men's Health and Wellness

Everything you should know about Tadalafil Vs Sildenafil

There are a lot of medications available to treat Erectile Dysfunction, Tadalafil and Sildenafil are most popular of all the medications. Both of the medications fall in the category of medications called phosphodiesterase type 5 (PDE5) inhibitors. Phosphodiesterase type 5 (PDE5) inhibitors prevent the working on a special enzyme (phosphodiesterase type 5) that is present in the walls of blood vessels. Phosphodiesterase type 5 (PDE5) inhibitors help in regulating the blood flow to the pulmonary blood vessels. By limiting the PDE5 from working, PDE5 inhibitors cause the muscles of the blood vessels to relax allowing smooth blood flow. Tadalafil and Sildenafil both work in a similar way.

Both medications need an external sexual stimulus to work. In the absence of sexual stimuli, the medicine won't work. Once aroused, the natural chemical PDE5 releases, only then do the PDE5 inhibitors start working. Once the natural chemical is released, PDE5 inhibitors prevent the working of PDE5 enzymes. In the absence of the PDE5 enzyme, smooth muscles present inside the penis begin to relax. This allows increased blood flow in the pulmonary blood vessels present around the male genitals allowing the penis to get an erection. Not only do these medications help in getting an erection, but they also help in increasing the time for which the erection lasts.

What are the major differences between Sildenafil and Tadalafil?


Sildenafil has been around since 1998. Erectile Dysfunction Medications are not a very old concept and Sildenafil is one of the oldest medications. Since it has been around for a long time, this means a lot of known about the strengths and side effects of the medication. Sildenafil starts working within an hour of taking the medicine and to enjoy the full effect of the medication it should be taken on an empty stomach. The effects of the medication are long lasting, lasting for four to five hours.

Sildenafil is also an active ingredient that is present in another Erectile Dysfunction medication, Viagra. Viagra was invented by a pharmaceutical company, Pfizer. Pfizer was the only pharmaceutical company that could legally manufacture Viagra till 2013 since only they had the patent.

The patent of this company was expired in the year 2013 after which other companies started to hop in and start their own production line to treat Erectile Dysfunction. These companies started manufacturing drugs that contain Sildenafil as their active ingredient.

If you ever see the name “Sildenafil” on the medication, you can be sure that contains the same active salts and ingredients as Viagra. The difference between the two is that Viagra is the branded version of the drug and the generic ones can be called the unbranded version of the same which makes them cheaper in comparison with Viagra.

Out of a lot of side effects of this medication, the most common side effects may include nausea, stuffy nose, headache, flushing and indigestion. Apart from these, there are some rare side effects that are mentioned in the leaflet present inside the box with the medication. It should be read very carefully before taking the medication. Even though there is a very low probability of any of the side effects to occur, but if they do one must consult a doctor.

There is no fixed medication course for Sildenafil. It is taken whenever required. It is usually taken 30 minutes before sexual intercourse. The usual dose for Sildenafil is 50 mg. The dose can be increased or decreased basis its effect. If the dose if ineffective, it can be increased up to 100 mg and if any side effects are experienced, the dose should be decreased to 25mg. About Ed pill, Sildenafil finds more info here. Generic Viagra is called “Blue pill” which pills to get hard fast.

The dosage can be different for different people depending on medical history. It is a must to consult the doctor before taking the medication as he can consult an appropriate starting dose.


In 2003, another company started an alternative drug to treat Erectile Dysfunction. This drug was named as Cialis and contained same active ingredient which is known as Tadalafil.

Eli Lilly owned the patent for Tadalafil up until November 2017. Just like with Viagra, now that the patent has expired other companies can legally make their own alternates of Tadalafil, which is the active ingredient in Cialis. And similar to how we have a generic version of Viagra, Tadalafil is known to be a generic version of the brand names Cialis and is comparatively cheaper than the brand itself.

Tadalafil can be taken in two formulations - one that can be taken “whenever required” (before sexual intercourse), and one that can be taken on a regular basis so that you can get involved in sexual intercourse anytime in between the doses. The ‘whenever required’ Tadalafil has a long-lasting effect. The effect can last up to 36 hours which gives the medication an advantage over Sildenafil that only lasts four to five hours. Tadalafil is preferred over Sildenafil as it allows one to be more spontaneous. Tadalafil also has an advantage over Sildenafil in a way that it works faster than Sildenafil. The effect of the medication is not affected by any kinds of food, which makes it another reason why some men prefer Tadalafil over Sildenafil.

The standard ‘whenever required’ dose of Tadalafil is 10 mg, this can be increased of decreased basis the effect of the medication. The dose can be increased up to 20 mg if the medicine is ineffective. The dose will also depend on your medical history, as Tadalafil may react with any other medication that you are taking. Consult your doctor before taking the medication, he can help prescribe an appropriate dose basis your medical history.

The everyday version of Tadalafil known under its brand name Cialis Daily is ideal for people who have sex twice or more than twice in a week. To experience the full effect of the medication, it should be taken regularly every day for five days. This way there is always a steady and constant dose of the medication in your body and one can have sexual intercourse anytime between the doses. This gives more spontaneity to the individual taking the medication.

Usually, the initial dose should not be more than 2.5 mg, but in case the dose seems to be ineffective it can be increased from 2.5 mg to 5 mg.

The side effect of Tadalafil is the same as the side effects of any other Erectile Dysfunction medication, these include - nausea, stuffy nose, dizziness, headaches, flushing, and indigestion. Apart from these, there are some low probability side effects as well all of which are mentioned on the leaflet present inside the box. One should always look at all the side effects before taking the medication. Apart from these side effects one of the major disadvantages of Tadalafil is that it stays in your body for a longer period that means if there are any side effects caused due to the medication they will also stay for a longer period.

Which one to use, Tadalafil or Sildenafil?

It's hard to say which medication is better than the other to treat Erectile Dysfunction in men. Different types of medication suit different people depending on the intensity of their impotence and their medical history. It's hard to find the best fit until you know which medication works best for you. Is has been seen that men often prefer Tadalafil over Sildenafil. Tadalafil works faster than Sildenafil and can be taken along with food. The effect lasts for much longer for Tadalafil as compared to Sildenafil. Having said that, some people prefer to stick with Sildenafil as Tadalafil doesn't suit them.

Both of the medication is easily available online. As per many people experienced Generic Villa is trusted and reasonable generic Viagra and Tadalafil(Cialis) online pharmacy. You can pick out with one suits you the best!

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